簡(jiǎn)介
Brief Introduction
OLExS型連續脂質(zhì)體擠出儀，主要解決脂質(zhì)體、納米粒等物料顆粒大、穩定性差， 包封率低、溫度要求高、原輔料貴等問(wèn)題，可對樣品粒子的大小和分布進(jìn)行有效控制。 OLExS 型連續脂質(zhì)體擠出儀具有快速操作、使用便捷、占地面積小等特點(diǎn)，為高校、企業(yè)脂質(zhì)體研發(fā)創(chuàng )造有趣穩定的操作體驗。
OLExS Online Liposome Extrusion System is the latest liposome extruder developed by Suzhou Aitesen Pharmaceutical Equipment Co., Ltd. It mainly solves the problems of large particle size, poor stability, low encapsulation efficiency, high temperature control requirement and high cost of raw materials and accessories. It can effectively control the size and distribution of sample particles. OLExS Online Liposome Extrusion System has the characteristics of fast operation, convenient use and small size. It creates interesting and stable operation experience for the research and development of liposome Preparation in universities and companies.
擠出原理
Extrusion Principle
脂質(zhì)體擠出的原理在于，通過(guò)一定的擠出動(dòng)力源將脂質(zhì)體樣品粒子進(jìn)行擠壓，使其在一定壓力條件下通過(guò)PC濾膜， 此壓力作為粒子過(guò)膜過(guò)程中的剪切力可使其達到粒徑控制的效果。不論形態(tài)、大小和分布都可得到極大改善。
The principle of liposome extrusion is that the particles of liposome sample are extruded by a certain extrusion power source to pass through the PC membrane under a certain pressure. The pressure acts as the shear force in the process of the particles passing through the membrane, which can achieve the effect of particle size control. The shape, size and distribubtion can be greatly improved.
技術(shù)參數
Technical Parameter
| 型號 MODEL | OLExS-L | OLExS-PI | OLExS-Pd |
|
最高壓力 [psi] Maximum pressure[psi] |
25 | 25 | 15 |
|
最終產(chǎn)品粒徑 [nm] Final product size [nm] |
50~1000 | 50~1000 | 50~1000 |
|
單批處理量[ml] Single batch volume[ml] |
5~2000 | 5~3000 | 100~5000 |
|
最高產(chǎn)品濃度[mg/ml] Maximum product concentration[mg/ml] |
200 | 200 | 200 |
|
工作溫度范圍 Operating temperature range |
5~80℃ | 5~80℃ | 5~80℃ |
|
設備材質(zhì) Equipment material |
SS316L | SS316L | SS316L |
|
動(dòng)力源類(lèi)型 Power Source Style |
Piston Pump | Piston Pump | Piston Pump |
|
擠出盤(pán)直徑[mm] Extruder Diameter[mm] |
47 | 90 | 143 |
|
擠出盤(pán)數量 Extruder Number |
2 | 2 | ≥2 |
|
最大流量(ml/min) Max Flow(ml/min) |
200 | 200 | 200 |
|
流量連續可調 Flow rate continuously adjustable |
√ | √ | √ |
|
配有高低壓保護功能 High and low voltage protection |
√ | √ | √ |
|
流量設定誤差%（ml/min） Flow setting error%（ml/min） |
≤±1% | ≤±1% | ≤±1% |
|
流量重復性誤差%（ml/min） Flow repeatability error%（ml/min） |
≤1% | ≤1% | ≤1% |
|
壓力脈動(dòng)（MPa） Pressure pulsation（MPa） |
≤0.2 | ≤0.2 | ≤0.2 |
|
壓力準確度（MPa） Pressure accuracy（MPa） |
≤0.1 | ≤0.1 | ≤0.1 |
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