7-酮石膽酸是一種膽汁酸衍生物，化學(xué)名為3α-羥基-7-氧代-5β-膽烷酸，CAS號(hào)為4651-67-6，分子式C24H38O4,分子量390.56。7-酮石膽酸是腸道細(xì)菌（如梭菌、乳酸桿菌和雙歧桿菌）代謝膽汁酸的產(chǎn)物，能夠抑制內(nèi)源性膽汁酸合成和膽汁中膽固醇的分泌，可能參與肝膽疾病的病理調(diào)節(jié)。作為熊去氧膽酸的和奧貝膽酸的關(guān)鍵中間體，用于治療膽結(jié)石、膽汁淤積性肝病等。
7-Keto lithocholic acid is a bile acid derivative, with the chemical name of 3α-hydroxy-7-oxo-5β-cholanoic acid, CAS number 4651-67-6, molecular formula C24H38O4, and molecular weight 390.56. 7-Keto lithocholic acid is a product of bile acid metabolism by intestinal bacteria (such as Clostridium, Lactobacillus and Bifidobacterium), which can inhibit endogenous bile acid synthesis and cholesterol secretion in bile, and may be involved in the pathological regulation of hepatobiliary diseases. As a key intermediate of ursodeoxycholic acid and obeticholic acid, it is used to treat gallstones, cholestatic liver disease, etc.
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